In-vitro bioactivity and cytotoxicity of polarized (Bi0.5Na0.5)TiO3 ceramics as a novel biomaterial for bone repair

Poled (Bi0.5Na0.5)TiO3 ceramics were firstly evaluated in the present study for their potential application as a novel biomaterial for bone repair. The formation of bone-like apatite was only observed on polarized surfaces showing a clear influence of polarity on its growth and maturation process after bioactivity tests. A non-cytotoxic effect of (Bi0.5Na0.5)TiO3 ceramics on MC3T3-E1 cells was shown in the viability test. Cells spread along the surface showed slight differences in shape and size due to polarity. Bioactive and non-cytotoxic behavior exhibited by poled (Bi0.5Na0.5)TiO3 ceramics makes them a promising material with tunable in-vitro properties for biomedical applications.