医学
铁蛋白
2019年冠状病毒病(COVID-19)
疾病
疾病严重程度
横断面研究
内科学
大流行
冠状病毒
血清铁蛋白
免疫学
严重急性呼吸综合征冠状病毒2型(SARS-CoV-2)
胃肠病学
传染病(医学专业)
病理
作者
Shani Dahan,Gad Segal,Itai Katz,Tamar Hellou,Michal Tietel,Gabriel Bryk,Howard Amital,Yehuda Shoenfeld,Amir Dagan
摘要
BACKGROUND Ferritin, the cellular protein storage for iron, has emerged as a key molecule in the immune system, orchestrating the cellular defense against inflammation. At the end of 2019, the novel severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) rapidly spread throughout China and other countries around the world, resulting in a viral pandemic. OBJECTIVES To evaluate the correlation between ferritin and disease severity in coronavirus disease-2019 (COVID-19). METHODS In this cross-sectional study, we obtained clinical and laboratory data regarding 39 hospitalized patients with confirmed COVID-19 from two hospitals in Israel. RESULTS A significant increase in ferritin levels was demonstrated in patients with moderate and severe disease, compared to patients with mild disease (P = 0.006 and 0.005, respectively). Severe patients had significantly higher levels of ferritin (2817.6 ng/ml) than non-severe patients (708.6 ng/ml) P = 0.02. CONCLUSIONS In this preliminary cross-sectional study, elevated ferritin levels were shown to correlate with disease severity in 39 patients from Israel with confirmed COVID-19 infection. Our results further strengthen the hypothesis that severe COVID-19 disease might be due to an underlying dysregulated hyperimmune response. In order to identify these patients early and prioritized resources, we believe that all patients with COVID-19 should be screened for hyperferritinemia.
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