蛋白酵素
组织蛋白酶B
组织蛋白酶
结直肠癌
癌症研究
半胱氨酸蛋白酶
间质细胞
半胱氨酸
癌
生物
蛋白酶
肿瘤进展
癌症
组织蛋白酶L
病理
酶
内科学
医学
生物化学
作者
Kieran Sheahan,Sania Shuja,Mary Jo Murnane
出处
期刊:PubMed
日期:1989-07-15
卷期号:49 (14): 3809-14
被引量:54
摘要
Many studies of malignant cells or tissues in culture have implicated cysteine proteases in the progression of malignancy. We have extended these observations by measuring quantitative and qualitative changes in the expression of cathepsin B-like and L-like cysteine proteases during the growth and development of human colorectal carcinomas. Data derived from matched pairs of normal colorectal mucosa and carcinoma tissue from 27 patients demonstrated that both cathepsin B-like and cathepsin L-like specific activities were significantly elevated (P less than 0.005) in the carcinoma tissue, while levels of endogenous cysteine protease inhibitor remained constant. Correlation of cathepsin enzyme activities with different stages of colorectal cancer demonstrated significantly higher cysteine protease activities in individuals with Dukes' A tumors (tumors confined to the bowel wall) than in patients with more advanced tumors (Dukes' B, C, or D tumors) (P less than 0.01-0.05). The relative proportion of activities contained in tumor epithelial and stromal elements remains to be elucidated. These results suggest an important role for cysteine proteases in the early progression of human colorectal carcinoma.
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