神经炎症
米诺环素
体外循环
齿状回
医学
麻醉
术后认知功能障碍
小胶质细胞
海马体
放射臂迷宫
神经发生
神经科学
心理学
炎症
内科学
认知
工作记忆
精神科
抗生素
微生物学
生物
作者
Yi Wang,Maro G. Machizawa,Turner C. Lisle,Cedric L. Williams,Ryon Clarke,Matthew J. Anzivino,Irving L. Krön,Kevin M. Lee
标识
DOI:10.3389/fncel.2022.780880
摘要
Post-operative cognitive dysfunction (POCD) can be a serious surgical complication, and patients undergoing cardiac procedures are at particular risk for POCD. This study examined the effect of blocking neuroinflammation on behavioral and neurogenic deficits produced in a rat model of cardiopulmonary bypass (CPB). Minocycline, a drug with established anti-inflammatory activity, or saline was administered daily for 30 days post-CPB. Treatment with minocycline reduced the number of activated microglia/macrophages observed in the dentate gyrus of the hippocampus at 6 months post-CPB, consistent with an anti-inflammatory action in this CPB model. Behavioral testing was conducted at 6 months post-CPB utilizing a win-shift task on an 8-arm radial maze. Minocycline-treated animals performed significantly better than saline-treated animals on this task after CPB. In addition, the CPB-induced reduction in adult neurogenesis was attenuated in the minocycline-treated animals. Together, these findings indicate that suppressing neuroinflammation during the early post-surgical phase can limit long-term deficits in both behavioral and neurogenic outcomes after CPB.
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