吲哚青绿
光热治疗
光动力疗法
光敏剂
石墨烯
金黄色葡萄球菌
抗菌活性
化学
活性氧
辐照
材料科学
核化学
光化学
纳米技术
医学
外科
细菌
生物化学
有机化学
核物理学
物理
遗传学
生物
作者
Yuan Chen,Wenlong Huang,Yuanhao Dong,Xiaotong Yu,Anchun Mo,Qiang Peng
标识
DOI:10.1166/jbn.2022.3236
摘要
Methicillin-resistant Staphylococcus aureus (MRSA) has become a serious threat to human's health. Recently, photodynamic/photothermal therapy (PDT/PTT) has emerged as promising strategies against antibiotics-resistant pathogens due to their broad antibacterial spectrum and negligible resistance. In this work, the photosensitizer indocyanine green (ICG) was loaded on graphene oxide (GO) nanosheets with good encapsulation efficiency high to 92.31%. Under near-infrared (NIR) irradiation, the anti-MRSA efficiency of GO (20 μg/ml), ICG (5 μg/ml) and ICG-GO (5 μg/ml-20 μg/ml) was 33.76%, 40.15% and 99.86%, respectively. We further showed that NIR irradiation mildly increased the temperature to 43.1 °C for ICG-GO, and lead to the highest reactive oxygen species (ROS) generation (316.51% and 157.11% compared to ICG alone and GO alone). In conclusion, ICG-GO has a great potential for antibacterial treatment due to its synergistic contact killing, photothermal and photodynamic activity.
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