Magneto-fluorescent superparamagnetic Fe3O4@SiO2@alginate/carbon quantum dots nanohybrid for drug delivery

材料科学 超顺磁性 药物输送 纳米颗粒 纳米技术 荧光 化学工程 磁性纳米粒子 粒径 傅里叶变换红外光谱 纳米材料 磁化 物理 量子力学 磁场 工程类
作者
Mohammad Jafar Molaei,Esmaeil Salimi
出处
期刊:Materials Chemistry and Physics [Elsevier BV]
卷期号:288: 126361-126361 被引量:18
标识
DOI:10.1016/j.matchemphys.2022.126361
摘要

Magneto-fluorescent nanohybrids are promising candidates for the application in drug delivery systems with simultaneous bioimaging. In this research, Fe3O4@SiO2 superparamagnetic nanoparticles were synthesized through the co-precipitation method to be used as a platform in drug delivery systems. The core/shell nanoparticles were coated with alginate (Fe3O4@SiO2@al). N-doped carbon quantum dots (CQDs) were also synthesized by the hydrothermal method and were used in a nanohybrid with the alginate-coated Fe3O4@SiO2 nanoparticles. The synthesized nanohybrid was used for drug loading and release experiments. Phase analysis, chemical bondings, magnetic properties, drug release characteristics, and particles' size and morphology were studied by XRD, FTIR, VSM, UV–Vis, AFM, TEM, and FESEM techniques, respectively. TEM studies showed the successful synthesis of Fe3O4@SiO2 nanoparticles with a mean particle size of around 20 nm. The Fe3O4@SiO2@al/CQDs nanoparticles showed a saturation magnetization of 42.46 emu/g. The N-doped CQDs have fluorescence emission by excitation in the range of 210–400 nm. The synthesized nanohybrid exhibited 81% drug loading, and a 25% and 38% drug release within 48 h at a pH of 7.4 and 5.5, respectively. The higher rate of drug release in a simulated tumor environment compared to normal tissues makes multifunctional magneto-fluorescent Fe3O4@SiO2@al/CQDs nanohybrid a promising candidate for simultaneous drug delivery and bioimaging.
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