已入深夜,您辛苦了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!祝你早点完成任务,早点休息,好梦!

Causal Relationship Between Sleep Traits and Risk of Systemic Lupus Erythematosus: A Two-Sample Mendelian Randomization Study

孟德尔随机化 多效性 计时型 医学 内科学 全基因组关联研究 肿瘤科 遗传学 单核苷酸多态性 生物 基因型 表型 遗传变异 昼夜节律 基因
作者
Ni Sang,Ruichen Gao,Meng-Yao Zhang,Zhenzhen Wu,Zhen-Gang Wu,Guo‐Cui Wu
出处
期刊:Frontiers in Immunology [Frontiers Media]
卷期号:13 被引量:25
标识
DOI:10.3389/fimmu.2022.918749
摘要

A correlation between sleep and systemic lupus erythematosus (SLE) has been observed in a number of prior investigations. However, little is known regarding the potential causative relationship between them. In this study, we selected genetic instruments for sleep traits from pooled data from published genome-wide association studies (GWAS). Independent genetic variants associated with six sleep-related traits (chronotype, sleep duration, short sleep duration, long sleep duration, insomnia, and daytime sleepiness) were selected as instrumental variables. A two-sample Mendelian randomization (TSMR) study was first conducted to assess the causal relationship between sleep traits and SLE (7219 cases versus 15,991 controls). The reverse MR analysis was then used to infer the causal relationship between SLE and sleep traits. Inverse variance weighted (IVW), MR Egger, Weighted median, and Weighted mode were applied to perform the primary MR analysis. MR Egger regression and the Mendelian randomization pleiotropy residual sum and outlier (MR-PRESSO) test were used to detect horizontal pleiotropy, and Cochran’s Q was used to detect heterogeneity. In studies of the effect of sleep traits on SLE risk, the IVW method demonstrated no causal relationship between chronotype, sleep duration, short sleep duration, long sleep duration, insomnia, daytime sleepiness and SLE risk. The remaining three methods agreed with the results of IVW. In studies of the effect of SLE on the risk of sleep traits, neither IVW, MR Egger, Weighted median, nor Weighted mode methods provided evidence of a causal relationship between SLE and the risk of sleep traits. Overall, our study found no evidence of a bidirectional causal relationship between genetically predicted sleep traits and SLE.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
诚心千筹完成签到,获得积分10
刚刚
vikoer发布了新的文献求助30
刚刚
AbeleChuang发布了新的文献求助10
刚刚
刚刚
guozizi发布了新的文献求助30
1秒前
1秒前
character577完成签到 ,获得积分10
3秒前
lizibelle发布了新的文献求助10
3秒前
夜雨声烦发布了新的文献求助10
4秒前
4秒前
共享精神应助小鲨鱼采纳,获得10
5秒前
乐乐应助百里如雪采纳,获得10
6秒前
陶醉海燕发布了新的文献求助10
7秒前
bkagyin应助张奕采纳,获得10
7秒前
11秒前
幸福大白发布了新的文献求助10
11秒前
mitty完成签到 ,获得积分10
14秒前
a1207732382发布了新的文献求助50
16秒前
17秒前
米缸完成签到,获得积分10
20秒前
幸福大白发布了新的文献求助10
21秒前
23秒前
帅气的马里奥完成签到 ,获得积分10
30秒前
oh完成签到,获得积分10
32秒前
33秒前
陶醉海燕发布了新的文献求助10
35秒前
激情的代曼完成签到,获得积分10
36秒前
38秒前
研友_VZG7GZ应助tanrui采纳,获得10
38秒前
deway发布了新的文献求助10
38秒前
43秒前
47秒前
百里如雪发布了新的文献求助10
48秒前
bkagyin应助wbh采纳,获得10
50秒前
se420发布了新的文献求助10
50秒前
瓶子完成签到 ,获得积分10
51秒前
阿童木完成签到 ,获得积分10
52秒前
53秒前
54秒前
悦悦应助wade采纳,获得10
55秒前
高分求助中
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Social Research Methods (4th Edition) by Maggie Walter (2019) 1030
A new approach to the extrapolation of accelerated life test data 1000
Indomethacinのヒトにおける経皮吸収 400
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 370
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3994330
求助须知:如何正确求助?哪些是违规求助? 3534764
关于积分的说明 11266452
捐赠科研通 3274665
什么是DOI,文献DOI怎么找? 1806413
邀请新用户注册赠送积分活动 883291
科研通“疑难数据库(出版商)”最低求助积分说明 809749