结构生物信息学
计算机科学
背景(考古学)
领域(数学)
蛋白质结构预测
生物信息学
对接(动物)
数据科学
万维网
计算生物学
蛋白质结构
生物
生物化学
古生物学
数学
纯数学
医学
护理部
作者
Vinícius Paiva,Isabela de Souza Gomes,Cleiton Rodrigues Monteiro,Murillo Ventura Mendonça,Pedro Martins,Charles Abreu Santana,Valdete Gonçalves-Almeida,Sandro C. Izidoro,Raquel C. de Melo-Minardi,Sabrina de A. Silveira
标识
DOI:10.1016/j.compbiomed.2022.105695
摘要
Proteins play a crucial role in organisms in nature. They are able to perform structural, catalytic, transport and defense functions in cells, among others. We understand that a variety of resources do exist to work with protein structural bioinformatics, which perform tasks such as protein modeling, protein docking, protein molecular dynamics, protein interaction, active and binding site prediction and mutation analysis. Nonetheless, they are generally spread all over different online repositories. For the students or professionals interested in working with protein structural bioinformatics, it may not be trivial to know what resources he/she should learn/use or where these could be accessed. Here, the main subareas in the field of protein structural bioinformatics are introduced with a brief description, and we point to and discuss several online resources, such as methods, databases and tools, in order to give an overview of this research field. Furthermore, we developed Protein Structural bioinformatics Overview (PreStO), a web tool available at http://bioinfo.dcc.ufmg.br/presto/, to organize and make it possible to retrieve these online resources based on a search term. We believe that this paper can be a starting point for potential bioinformaticians to trace a path that can be followed to build competencies and achieve knowledge milestones in the context of protein structural bioinformatics.
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