Link of BIN1, CLU, and fIDE Gene Polymorphisms with the Susceptibility of Alzheimer’s Disease: Evidence from a Meta-analysis

荟萃分析 优势比 凝集素 遗传关联 遗传模型 置信区间 疾病 内科学 等位基因 医学 肿瘤科 基因型 子群分析 阿尔茨海默病 遗传学 生物信息学 生物 基因 单核苷酸多态性 细胞凋亡
作者
Md. Abdul Aziz,Ghulam Md Ashraf,Mohammad Safiqul Islam
出处
期刊:Current Alzheimer Research [Bentham Science Publishers]
卷期号:19 (4): 302-316 被引量:1
标识
DOI:10.2174/1567205019666220511140955
摘要

Background: Alzheimer’s disease (AD) is the most common form of neurodegenerative disorder. The association of BIN1, CLU, and IDE genetic polymorphisms with AD risk have been evaluated overtimes that produced conflicting outcomes. Objective: We performed this meta-analysis to investigate the contribution of BIN1 (rs744373 and rs7561528), CLU (rs11136000 and rs9331888), and IDE (rs1887922) polymorphisms to AD risk. Methods: From a systemic literature search up to July 15, 2021, we included 25 studies with rs744373, 16 studies with rs7561528, 37 studies with rs11136000, 16 studies with rs9331888, and 4 studies with rs1887922. To analyze the correlation, we constructed seven genetic models that used odds ratio and 95% confidence intervals. We used RevMan 5.4 for meta-analysis. Results: Our study suggests that BIN1 rs744373 is associated with a significantly increased risk of AD in five genetic models (OR>1). Again, CLU rs11136000 showed reduced association in all genetic models (OR<1). CLU rs9331888 revealed an increased association in two models (OR>1). The IDE rs1887922 showed significantly increased risk in four models (OR>1). From subgroup analysis, a significantly increased risk of AD was observed in Caucasians and Asians for BIN1 rs744373. Again, BIN1 rs7561528 showed a significantly enhanced risk of AD only in Caucasians. CLU rs11136000 showed significantly reduced risk in Caucasians but rs9331888 showed increased risk in the same ethnicity. Conclusion: Our meta-analysis confirms the association of BIN1 rs744373, CLU rs9331888, and IDE rs1887922 polymorphisms with an increased risk of AD, especially in Caucasians. Again, CLU rs11136000 is associated with reduced AD risk in the overall population and Caucasians.
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