电泳剂
酮
亲核细胞
化学
组合化学
锌
有机化学
催化作用
作者
Michael S. West,Julia E. Pia,Sophie Rousseaux
出处
期刊:Organic Letters
[American Chemical Society]
日期:2022-07-06
卷期号:24 (32): 5869-5873
被引量:2
标识
DOI:10.1021/acs.orglett.2c01634
摘要
Ketone homoenolates are intermediates with both nucleophilic and electrophilic properties. While there are several reports on their use as nucleophiles, there are few reports on their potential as electrophiles. Herein, we report the use of ketone zinc/copper homoenolates as electrophiles in the synthesis of 1- and 1,2-substituted cyclopropylamines. We found that CuCN·2LiCl is essential to produce a more reactive homoenolate intermediate. We also report a facile telescoped sequence from β-substituted enones toward 1,2-disubstituted cyclopropylamines.
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