三叉神经节
神经科学
电池类型
生物
神经节
偏头痛
三叉神经
细胞
转录因子
基因
解剖
医学
遗传学
内科学
感觉系统
作者
Lanbo Yang,Mengyi Xu,Shamsuddin A. Bhuiyan,Jia Li,Jun Zhao,Randall J. Cohrs,Justin T. Susterich,Sylvia Signorelli,Ursula Green,James R. Stone,Dan Levy,Jochen K. Lennerz,William Renthal
出处
期刊:Neuron
[Elsevier]
日期:2022-06-01
卷期号:110 (11): 1806-1821.e8
被引量:76
标识
DOI:10.1016/j.neuron.2022.03.003
摘要
Sensitization of trigeminal ganglion neurons contributes to primary headache disorders such as migraine, but the specific neuronal and non-neuronal trigeminal subtypes that are involved remain unclear. We thus developed a cell atlas in which human and mouse trigeminal ganglia are transcriptionally and epigenomically profiled at single-cell resolution. These data describe evolutionarily conserved and human-specific gene expression patterns within each trigeminal ganglion cell type, as well as the transcription factors and gene regulatory elements that contribute to cell-type-specific gene expression. We then leveraged these data to identify trigeminal ganglion cell types that are implicated both by human genetic variation associated with migraine and two mouse models of headache. This trigeminal ganglion cell atlas improves our understanding of the cell types, genes, and epigenomic features involved in headache pathophysiology and establishes a rich resource of cell-type-specific molecular features to guide the development of more selective treatments for headache and facial pain.
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