促黄体激素
排卵
卵泡期
黄体期
内科学
内分泌学
促性腺激素
促性腺激素释放激素
促卵泡激素
雌激素
孕激素
激素
胚胎移植
卵泡
男科
生物
医学
胚胎
细胞生物学
作者
Xuefeng Lu,Yanping Kuang
出处
期刊:Cambridge University Press eBooks
[Cambridge University Press]
日期:2022-04-30
卷期号:: 93-100
标识
DOI:10.1017/9781316477021.013
摘要
The reproductive cycle requires complex interactions and feedback between gonadotropin-releasing hormone (GnRH), the gonadotropins follicle-stimulating hormone (FSH) and luteinizing hormone (LH), and the ovarian sex steroid hormones estrogen and progesterone. To improve the success rate of in vitro fertilization-embryo transfer (IVF-ET) by optimizing oocyte retrieval, controlled ovarian stimulation (COS) has been widely performed. Exogenous gonadotropins were used to achieve supraphysiological levels during the follicular phase to override the process of dominant follicle selection and enable multiple follicular recruitment, which lead to a rapidly increasing serum estradiol level and induce a premature LH surge. GnRH agonist (GnRHa) and GnRH antagonist were used to prevent the premature LH surge and premature ovulation [1]. In 2003, based on ultrasonographic studies, Baerwald et al. demonstrated that multiple cohorts or “waves” of 2–5 mm follicles were recruited continuously during a menstrual cycle, including in the luteal phase [2;3].
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