螺旋动脉
滋养层
运动性
机械敏感通道
蜕膜
子痫前期
细胞生物学
怀孕
免疫学
生物
医学
神经科学
胎盘
内科学
胎儿
遗传学
受体
离子通道
作者
Baozhen Xie,Haiwang Wu,Jing Li,Xiaoli Lv,Yuexi Zhou,Qing‐Ying Yu,Shichao Cui,Lihua Zeng,Jingwei Li,Xian Huang,Jie Gao,Songping Luo
出处
期刊:Placenta
[Elsevier]
日期:2022-06-01
卷期号:123: 46-53
被引量:1
标识
DOI:10.1016/j.placenta.2022.03.013
摘要
During the first trimester of pregnancy, cytotrophoblasts (CTBs) differentiate into extravillous trophoblasts (EVTs). EVTs migrate from villus to decidua, invade maternal spiral arteries (SAs) and more strikingly, they migrate against blood flow along the vessels and replace endothelial cells (ECs), completing SA remodeling. Studies have indicated that trophoblast cells are mechanosensitive. They assemble ECs, which can align in the direction of fluid flow. However, how they sense blood flow and transform mechanical stimulations into chemical signals remain largely unexplored. What factors trigger their motility? what are the potential and major factors that guide them to find their path and empower them to migrate against flow? To answer these intricate questions, this review provides some of the novel aspects and sheds new insights into clinical applications.
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