RNA结合蛋白
计算生物学
翻译(生物学)
小RNA
RNA剪接
核糖核酸
生物发生
生物
环状RNA
生物信息学
遗传学
基因
信使核糖核酸
作者
Nan Wu,Javeria Qadir,Burton B. Yang
标识
DOI:10.1016/j.molmed.2022.04.001
摘要
In the published version of Figure 2, the term 'circRNA' is mispresented as 'ciRNA' due to an editing error. This has been corrected in the revised figure. We apologize for any confusion this caused. CircRNA perspective: new strategies for RNA therapyWu et al.Trends in Molecular MedicineFebruary 26, 2022In BriefCircular RNA (circRNA) is generated via intronic complementary sequence (ICS)-driven, RNA binding protein (RBP)-driven, or lariat-mediated back-splicing (BS) biogenesis models. The physiological and pathological functions of circRNAs occur through miRNA sponging, interacting with circRNA binding proteins (cRBPs), protein translation, or transcriptional regulation. CircRNAs play roles in regulation of cancer development, cardiovascular diseases, neurogenesis and neurological disorders, and metabolic diseases. Full-Text PDF
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