吸收(声学)
点源
离子交换树脂
材料科学
校准
校准曲线
基质(化学分析)
分析化学(期刊)
化学
光学
物理
色谱法
复合材料
核物理学
检出限
量子力学
作者
Qingyang Wei,Zhenlei Lyu,Nianming Jiang,Zhihan Deng,Tingfa Xu,Lichao Sun,Xuefeng Zhang,Zuo‐Xiang He,Yaqiang Liu,Tianyu Ma
标识
DOI:10.1016/j.apradiso.2022.110256
摘要
In single-photon emission computed tomography (SPECT), a micro-sized 99mTc source is routinely used for performance measurement, geometry calibration, and system matrix generation. Therefore, a micro-sized source is critical in nuclear instrument production and quality control. Standard methods can only produce a point source with a large size and low total activity, as they are limited by the concentration of the 99mTc solution. The absorption of 99mTc on ion exchange resins has been used; however, few studies have quantitatively evaluated the absorption process and optimized the source activity. This paper proposes a procedure for producing a micro-sized 99mTc resin source with a super-high concentration, as well as a method for the fast measurement of the point source time-activity curve (TAC). Experiments on two resin point sources with diameters of 0.681 mm and 0.326 mm were carried out. Two semi-empirical models, including the first kinetic model and the pseudo-second-order rate equation model, were used to fit TACs. The results show the first kinetic model fit better, which suggests an acquisition time of 2-4 h is needed for optimization. The verification experiment demonstrates a resin point source with a diameter of 0.35 mm and total activity of 10.6 mCi (i.e., 59.1 Ci/mL concentration) was produced.
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