计算生物学
生物信息学
主要组织相容性复合体
计算机科学
药物发现
人工智能
抗原
数据科学
生物信息学
生物
免疫学
遗传学
基因
作者
Morten Nielsen,Nicola Ternette,Carolina Barra
标识
DOI:10.1080/14789450.2022.2064278
摘要
The comprehensive collection of peptides presented by major histocompatibility complex (MHC) molecules on the cell surface is collectively known as the immunopeptidome. The analysis and interpretation of such data sets holds great promise for furthering our understanding of basic immunology and adaptive immune activation and regulation, and for direct rational discovery of T cell antigens and the design of T-cell-based therapeutics and vaccines. These applications are, however, challenged by the complex nature of immunopeptidome data.Here, we describe the benefits and shortcomings of applying liquid chromatography-tandem mass spectrometry (MS) to obtain large-scale immunopeptidome data sets and illustrate how the accurate analysis and optimal interpretation of such data is reliant on the availability of refined and highly optimized machine learning approaches.Further, we demonstrate how the accuracy of immunoinformatics prediction methods within the field of MHC antigen presentation has benefited greatly from the availability of MS-immunopeptidomics data, and exemplify how optimal antigen discovery is best performed in a synergistic combination of MS experiments and such in silico models trained on large-scale immunopeptidomics data.
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