Efficacy and Safety of Shuganjieyu Capsule Alone or in Combination with Other Antidepressants in the Treatment of Postpartum Depression: A Meta-Analysis

哈姆德 医学 不利影响 内科学 萧条(经济学) 荟萃分析 产后抑郁症 抗抑郁药 胃肠病学 显著性差异 怀孕 生物 遗传学 宏观经济学 经济 海马体
作者
Lingning Wang,Yan Fan,Jiangmen He,Heng Liu,Feng Chen,Hongying Dan,Juan Zhao,Jiao Zhang,Tao Wang,Xinru Liu
出处
期刊:Evidence-based Complementary and Alternative Medicine [Hindawi Publishing Corporation]
卷期号:2022: 1-16 被引量:1
标识
DOI:10.1155/2022/5260235
摘要

To evaluate the efficacy and safety of Shuganjieyu capsule alone or in combination with other antidepressants in the treatment of postpartum depression.Related control and randomized studies till August 1, 2021, were retrieved from the following databases: PubMed, Cochrane, CNKI, CMB, Wan-Fang, and VIP. Outcomes included HAMD reduction from baseline, response rate, and adverse events rate. Review Manager 5.3 was used in the present meta-analysis.16 studies including 1409 participants were included in the present study. In comparison of single Shuganjieyu capsule versus regular antidepressant, 8, 6, and 4-week HAMD reduction of the Shuganjieyu group were significantly higher (8-week MD: 3.1 (1.54, 4.66), p < 0.0001; 6-week MD: 0.71 (0.10, 1.31), p=0.02; and 4-week MD: 0.82 (0.34, 1.30), p=0.0008), response rates were comparable for the two groups (OR: 1.51 (0.87, 2.63), p=0.014), and the adverse event rate of the Shuganjieyu group was significantly lower (OR: 0.22 (0.15, 0.32), p < 0.00001). In comparison of combination of Shuganjieyu capsule with regular antidepressant versus regular antidepressant alone, the 8, 6, 4, 2, and 1-week HAMD reduction and response rate of combination of Shuganjieyu with the regular antidepressant group were significantly larger (8-week MD: 3.2 (1.34, 5.06), p=0.0007; 6-week MD: 4.00 (2.72, 5.28), p < 0.00001; 4-week MD: 3.33 (1.94,4.73), p < 0.00001; 2-week MD: 2.69 (1.34, 4.03), p < 0.0001; 1-week MD: 2.27 (0.69, 3.86), p=0.005; and response rate OR: 4.69 (2.27, 9.68), p < 0.0001) and the adverse event rate was comparable for the two groups (OR: 1.26 (0.73, 2.17), p=0.41).Compared with regular antidepressants, single Shuganjieyu capsule has similar efficacy and better safety profile; when Shuganjieyu capsule is combined with regular antidepressants, the efficacy is improved significantly without increasing adverse events. Therefore, Shuganjieyu capsule was effective and safe for postpartum, making it worth further investigation and popularization.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
小郭完成签到 ,获得积分10
1秒前
科研通AI2S应助科研通管家采纳,获得10
2秒前
平淡访冬完成签到 ,获得积分10
3秒前
Jialing完成签到,获得积分10
6秒前
mol完成签到 ,获得积分10
10秒前
科研小白发布了新的文献求助10
19秒前
大金鱼完成签到 ,获得积分10
21秒前
风清扬完成签到,获得积分0
22秒前
1523完成签到 ,获得积分10
31秒前
35秒前
38秒前
缥缈绮兰发布了新的文献求助10
39秒前
秋秋糖xte发布了新的文献求助10
41秒前
又又完成签到,获得积分10
41秒前
韧迹完成签到 ,获得积分0
44秒前
郭德久完成签到 ,获得积分0
47秒前
番茄小超人2号完成签到 ,获得积分10
48秒前
qwe发布了新的文献求助10
51秒前
笨笨忘幽完成签到,获得积分10
51秒前
美丽完成签到 ,获得积分10
56秒前
CLTTT完成签到,获得积分10
59秒前
居里姐姐完成签到 ,获得积分10
1分钟前
现实的曼安完成签到 ,获得积分10
1分钟前
sunzhengkui完成签到,获得积分10
1分钟前
MrChew完成签到 ,获得积分10
1分钟前
凌露完成签到 ,获得积分0
1分钟前
秋秋糖xte完成签到,获得积分10
1分钟前
hsrlbc完成签到,获得积分10
1分钟前
活力的邴完成签到 ,获得积分10
1分钟前
活力的邴关注了科研通微信公众号
1分钟前
fanssw完成签到 ,获得积分10
1分钟前
忧虑的静柏完成签到 ,获得积分10
1分钟前
1分钟前
耿教授发布了新的文献求助10
1分钟前
小猪完成签到 ,获得积分10
1分钟前
2分钟前
SciGPT应助科研通管家采纳,获得10
2分钟前
背后海亦发布了新的文献求助10
2分钟前
慕青应助沈万熙采纳,获得10
2分钟前
BCKT完成签到,获得积分10
2分钟前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Cognitive Neuroscience: The Biology of the Mind 1000
Technical Brochure TB 814: LPIT applications in HV gas insulated switchgear 1000
Immigrant Incorporation in East Asian Democracies 600
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
A Preliminary Study on Correlation Between Independent Components of Facial Thermal Images and Subjective Assessment of Chronic Stress 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3968559
求助须知:如何正确求助?哪些是违规求助? 3513358
关于积分的说明 11167340
捐赠科研通 3248714
什么是DOI,文献DOI怎么找? 1794453
邀请新用户注册赠送积分活动 875065
科研通“疑难数据库(出版商)”最低求助积分说明 804664