Effect of feed frame on lubricant sensitivity during upscaling from a compaction simulator to a rotary tablet press

润滑油 硬脂酸镁 材料科学 压片 极限抗拉强度 微晶纤维素 压实 复合材料 润滑 赋形剂 剂型 纤维素 色谱法 化学 化学工程 工程类
作者
Cedrine de Backere,Thomas De Beer,Chris Vervaet
出处
期刊:International Journal of Pharmaceutics [Elsevier BV]
卷期号:616: 121562-121562 被引量:9
标识
DOI:10.1016/j.ijpharm.2022.121562
摘要

Internal lubrication can be associated with reduced tabletability. Deformation mechanism, lubricant type, lubricant blending time and paddle speed (PS) of the forced feeder are known to be influenceable factors. This study investigated the effect of lubricant blending time and PS of forced feeders on the tensile strength of lubricated microcrystalline cellulose (MCC) and lactose tablets. Magnesium stearate (MgSt), sodium stearyl fumarate (SSF) and stearic acid (SA) were used as lubricants. Tablets were produced on a compaction simulator and a rotary tablet press to investigate lubricant sensitivity during upscaling. Lubricant sensitivity was found higher for MCC compared to lactose which was attributed to the higher plasticity of MCC. The reduction in tensile strength upon lubricant addition followed the order: MgSt > SSF > SA; which could be linked to particle size, specific surface area and particle shape of the lubricants. Although differences in tensile strength were observed between the lubricant types, comparable ejection forces were obtained. The impact of PS on tensile strength was higher compared to lubricant blending time for both tableting machines. A good correlation of tensile strength and lubricant sensitivity between the compaction simulator and rotary tablet press was observed based on the calculation of paddle passes (NPP).
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