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Polyethylene glycol-modified mesoporous polydopamine nanoparticles co-loaded with dimethylcurcumin and indocyanine green for combination therapy of castration-resistant prostate cancer

吲哚青绿 纳米颗粒 生物相容性 材料科学 聚乙二醇 核化学 动态光散射 化学 药物输送 纳米技术 有机化学 医学 外科 冶金
作者
Jun Hong,Ya-Ting Tang,Mengting Zhou,Jing Deng,Hang Hu,Defeng Xu
出处
期刊:Journal of Drug Delivery Science and Technology [Elsevier]
卷期号:69: 103158-103158 被引量:7
标识
DOI:10.1016/j.jddst.2022.103158
摘要

Herein, polyethylene glycol-modified mesoporous polydopamine (PEG-MPDA) nanoparticles co-loaded with indocyanine green (ICG) and dimethylcurcumin (ASC-J9, DMC) were developed for combination therapy of castration-resistant prostate cancer. MPDA nanoparticles were prepared and surface modified with methoxypolyethylene glycol amine (mPEG-NH2, M.W. 2000 and 5000). The prepared PEG2000-MPDA and PEG5000-MPDA nanoparticles were characterized by dynamic light scattering (DLS), scanning electron microscopy (SEM), transmission electron microscopy (TEM), and atomic force microscopy (AFM). ICG and DMC co-loaded PEG2000-MPDA and PEG5000-MPDA nanoparticles ([email protected]&DMC and [email protected]&DMC) were prepared by a solvent diffusion method. The decrease in drug feeding ratios results in decline in drug loading content and increase in drug encapsulation rate. [email protected]&DMC and [email protected]&DMC nanoparticles with relatively high drug loading content (ICG 10.0 ± 0.5% and 9.2 ± 0.3%, DMC 6.7 ± 0.2% and 6.4 ± 0.3%) were selected for further studies. The hydrodynamic diameters of these two nanoparticles are between 200 and 300 nm. These two nanoparticles display enhanced stability of ICG in aqueous solution, near-infrared (NIR) laser irradiation-promoted DMC release, efficient photothermal effect, enhanced cellular uptake, and excellent biocompatibility. In in vitro antitumor effect study, these two nanoparticles exhibit enhanced antitumor effect against 22Rv1 cells as compared to ICG&DMC mixture upon 808 nm laser irradiation. Western blot analyses indicate that these two nanoparticles enhance the degradation of androgen receptor (AR) significantly. This work provides a novel strategy and an effective co-delivery system for combinational castration-resistant prostate cancer therapy.
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