再生(生物学)
促炎细胞因子
体内
明胶
化学
免疫系统
牙周炎
伤口愈合
药理学
细胞生物学
炎症
微生物学
免疫学
医学
牙科
生物
生物化学
生物技术
作者
Xuexiang Zhang,Mohammad Mahdi Hasani‐Sadrabadi,Jana Zárubová,Erfan Dashtimoghadam,Reihaneh Haghniaz,Ali Khademhosseini,Manish J. Butte,Alireza Moshaverinia,Tara Aghaloo,Song Li
出处
期刊:Matter
[Elsevier]
日期:2021-12-08
卷期号:5 (2): 666-682
被引量:62
标识
DOI:10.1016/j.matt.2021.11.017
摘要
Periodontal diseases are caused by microbial infection and the recruitment of destructive immune cells. Current therapies mainly deal with bacteria elimination, but the regeneration of periodontal tissues remains a challenge. Here we developed a modular microneedle (MN) patch that delivered both antibiotic and cytokines into the local gingival tissue to achieve immunomodulation and tissue regeneration. This MN patch included a quickly dissolvable gelatin membrane for an immediate release of tetracycline and biodegradable GelMA MNs that contained tetracycline-loaded poly(lactic-co-glycolic acid) nanoparticles and cytokine-loaded silica microparticles for a sustained release. Antibiotic release completely inhibited bacteria growth, and the release of IL-4 and TGF-β induced the repolarization of anti-inflammatory macrophages and the formation of regulatory T cells in vitro. In vivo delivery of MN patch into periodontal tissues suppressed proinflammatory factors and promoted pro-regenerative signals and tissue healing, which demonstrated the therapeutic potential of local immunomodulation for tissue regeneration.
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