乙醛
醇脱氢酶
体内
乙醇
癌症研究
醛脱氢酶
化学
肿瘤进展
药理学
生物化学
医学
生物
酶
基因
生物技术
作者
Yu Zhang,Di‐Wei Zheng,Chu‐Xin Li,Pei Pan,Simin Zeng,Ting Pan,Xian‐Zheng Zhang
标识
DOI:10.1002/smtd.202100951
摘要
Taking inspiration from percutaneous ethanol injection (PEI) for tumor ablation, an acetaldehyde generator (SC@ZIF@ADH) is constructed for tumor treatment by modifying a metal-organic framework nanocarrier (ZIF), which is loaded with alcohol dehydrogenase (ADH), onto the surface of Saccharomyces cerevisiae (SC). Oral administration of SC@ZIF@ADH can target tumor via mannose-mediated targeting to tumor associated macrophages (TAMs) and generate ethanol at the hypoxic tumor areas. Ethanol is subsequently catalyzed to toxic acetaldehyde by ADH, inducing tumor cells apoptosis and polarizing TAMs toward the anti-tumor phenotype. In vivo animal results show that this acetaldehyde generator can cause a temulence-like reaction in the tumor, significantly inhibiting tumor progression, and might provide an intelligent and nonsurgical substitute for PEI therapy.
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