链脲佐菌素
丙二醛
糖尿病
蘑菇
医学
超氧化物歧化酶
抗氧化剂
糖尿病肾病
传统医学
内科学
内分泌学
化学
食品科学
氧化应激
生物化学
作者
Nuniek Ina Ratnaningtyas,Hernayanti Hernayanti,Nuraeni Ekowati,Fajar Husen
出处
期刊:IOP conference series
[IOP Publishing]
日期:2021-12-01
卷期号:948 (1): 012078-012078
被引量:6
标识
DOI:10.1088/1755-1315/948/1/012078
摘要
Abstract Diabetes mellitus (DM) is a metabolic disease with an increasing prevalence. An increase in free radicals and AGEs can cause glomerular cell damage which can lead to inflammation and DM nephropathy. WHO has recommended DM treatment by using herbal medicines that have minimal side effects and have a lot of biological activity to prevent complications. Coprinus comatus (O.F. Mull.) is known as immunomodulatory, anti-inflammatory and antidiabetic agent. The research used C. comatus cultivated in Cianjur. The basidiome of this mushroom has slightly oval and small with height of 8-12 cm and thickness of 2-3 cm. The research included six groups of male Wistar rats: Group 1 received no treatment, Groups 2–6 were administered 45 mg/kg BW streptozotocin once, Group 3 was administered 45 mg/kg BW metformin, Groups 4, 5, and 6 were administered 250, 500, and 750 mg/kg BW of C. comatus fruit body ethanol extract respectively for 14 days. The superoxide dismutase (SOD), malondialdehyde (MDA), hepcidin and β2 microglobulin (B2M) levels were evaluated. Data were analyzed using analysis of variance and Duncan’s multiple-range tests. The results showed that dose of 500 mg was effective in increasing SOD and decreasing hepcidin, B2M and MDA levels.
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