A high-dosage microneedle for programmable lidocaine delivery and enhanced local long-lasting analgesia

利多卡因 透皮 盐酸利多卡因 局部麻醉剂 药物输送 医学 输送系统 生物医学工程 体内 麻醉 材料科学 药理学 纳米技术 生物 生物技术
作者
Ze Qiang Zhao,Bao Li Zhang,Hua Qing Chu,Ling Liang,Bo Zhi Chen,Hui Zheng,Xin Dong Guo
出处
期刊:Biomaterials advances 卷期号:133: 112620-112620 被引量:34
标识
DOI:10.1016/j.msec.2021.112620
摘要

Considering the staggering global prevalence of local pain affecting hundreds of million individuals, it is of great significance to develop advanced dosage forms or delivery systems for analgesic therapy to fulfill clinical applicability. In this study, a hydrogel microneedles (MNs) system made out of gelatin-methacryloyl (GelMA) was designed to deliver lidocaine hydrochloride (LiH) in a sustained manner, and the drug loading capacity of the GelMA MNs was increased considerably by using the backing layer reservoir. The in vitro and in vivo tests showed that the fabricated GelMA MNs are strong enough for reliable skin application, and achieve high drug delivery efficiency as compared with the commercial lidocaine patches. The Spared-nerve injury (SNI) model of rats was also prepared to test behavioral pain sensitivity in response to mechanical stimuli, which proved that the LiH/GelMA MNs can enhance and prolong the anesthetic effect of LiH. In addition, with biosafety evaluation in rats, the MNs treated site restored to normal appearance within several hours of application and no dermatosis-related side effects or behavior disorders were observed during the experiment. Together these results indicated that the use of GelMA MNs for transdermal delivery of LiH is an effective, safe and simple treatment method to provide a better choice for local long-lasting analgesia.
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