肺
氧化应激
细胞凋亡
MAPK/ERK通路
放射治疗
医学
肺炎
肠道菌群
癌症研究
炎症
药理学
免疫学
生物
内科学
信号转导
细胞生物学
生物化学
作者
Zhiyuan Chen,He Xiao,Jiali Dong,Yuan Li,Bin Wang,Saijun Fan,Ming Cui
出处
期刊:Antioxidants
[MDPI AG]
日期:2021-12-28
卷期号:11 (1): 65-65
被引量:16
标识
DOI:10.3390/antiox11010065
摘要
Radiation pneumonia is a common and intractable side effect associated with radiotherapy for chest cancer and involves oxidative stress damage and inflammation, prematurely halting the remedy and reducing the life quality of patients. However, the therapeutic options for the complication have yielded disappointing results in clinical application. Here, we report an effective avenue for fighting against radiation pneumonia. Faecal microbiota transplantation (FMT) reduced radiation pneumonia, scavenged oxidative stress and improved lung function in mouse models. Local chest irradiation shifted the gut bacterial taxonomic proportions, which were preserved by FMT. The level of gut microbiota-derived PGF2α decreased following irradiation but increased after FMT. Experimental mice with PGF2α replenishment, via an oral route, exhibited accumulated PGF2α in faecal pellets, peripheral blood and lung tissues, resulting in the attenuation of inflammatory status of the lung and amelioration of lung respiratory function following local chest irradiation. PGF2α activated the FP/MAPK/NF-κB axis to promote cell proliferation and inhibit apoptosis with radiation challenge; silencing MAPK attenuated the protective effect of PGF2α on radiation-challenged lung cells. Together, our findings pave the way for the clinical treatment of radiotherapy-associated complications and underpin PGF2α as a gut microbiota-produced metabolite.
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