医学
头颈部癌
头颈部
疾病
头颈部鳞状细胞癌
基底细胞
癌症
人乳头瘤病毒
内科学
肿瘤科
放射治疗
作者
Mayur D Mody,James W Rocco,Sue S Yom,Robert I Haddad,Nabil F Saba
出处
期刊:The Lancet
[Elsevier]
日期:2021-12-18
卷期号:398 (10318): 2289-2299
被引量:21
标识
DOI:10.1016/s0140-6736(21)01550-6
摘要
Head and neck cancer is the seventh most common type of cancer worldwide and comprise of a diverse group of tumours affecting the upper aerodigestive tract. Although many different histologies exist, the most common is squamous cell carcinoma. Predominant risk factors include tobacco use, alcohol abuse, and oncogenic viruses, including human papillomavirus and Epstein-Barr virus. Head and neck malignancies remain challenging to treat, requiring a multidisciplinary approach, with surgery, radiotherapy, and systemic therapy serving as key components of the treatment of locally advanced disease. Although many treatment principles overlap, treatment is generally site-specific and histology-specific. This Seminar outlines the current understanding of head and neck cancer and focuses on treatment principles, while also discussing future directions to improve the outcomes of patients with these malignancies.
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