Surgery versus Radiofrequency Ablation for Small Hepatocellular Carcinoma: A Randomized Controlled Trial (SURF Trial)

医学 四分位间距 危险系数 肝细胞癌 射频消融术 随机对照试验 置信区间 外科 米兰标准 临床终点 内科学 烧蚀 肝移植 移植
作者
Tadatoshi Takayama,Kiyoshi Hasegawa,Namiki Izumi,Masatoshi Kudo,Mitsuo Shimada,Naoki Yamanaka,Masafumi Inomata,Shuichi Kaneko,Hisashi Nakayama,Yoshikuni Kawaguchi,Kosuke Kashiwabara,Ryosuke Tateishi,Shuichiro Shiina,Kazuhiko Koike,Yutaka Matsuyama,Masao Omata,Masatoshi Makuuchi,Norihiro Kokudo
出处
期刊:Liver cancer [Karger Publishers]
卷期号:11 (3): 209-218 被引量:86
标识
DOI:10.1159/000521665
摘要

It remains unclear which surgery or radiofrequency ablation (RFA) is the more effective treatment for small hepatocellular carcinoma (HCC). We aimed to compare survival between patients undergoing surgery (surgery group) and patients undergoing RFA (RFA group).We conducted a randomized controlled trial involving 49 institutions in Japan. Patients with Child-Pugh scores ≤7, largest HCC diameter ≤3 cm, and ≤3 HCC nodules were considered eligible. The co-primary endpoints were recurrence-free survival (RFS) and overall survival (OS). The current study reports the final result of RFS, and the follow-up of OS is still ongoing.During 2009-2015, 308 patients were registered. After excluding ineligible patients, the surgery and RFA groups included 150 and 151 patients, respectively. Baseline factors did not differ significantly between the groups. In both groups, 90% of patients had solitary HCC. The median largest HCC diameter was 1.8 cm (interquartile range [IQR], 1.5-2.2 cm) in the surgery group and 1.8 cm (IQR, 1.5-2.3 cm) in the RFA group. The median procedure duration (274 vs. 40 min, p < 0.01) and the median duration of hospital stay (17 days vs. 10 days, p < 0.01) were longer in the surgery group than in the RFA group. RFS did not differ significantly between the groups as the median RFS was 3.5 (95% confidence interval [CI], 2.6-5.1) years in the surgery group and 3.0 (95% CI, 2.4-5.6) years in the RFA group (hazard ratio, 0.92; 95% CI, 0.67-1.25; p = 0.58).Our study did not show which surgery or RFA is the better treatment option for small HCC.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
丫丫发布了新的文献求助10
1秒前
huangyikun发布了新的文献求助10
1秒前
叔铭完成签到,获得积分10
2秒前
大个应助ZONG采纳,获得10
4秒前
4秒前
Ma完成签到,获得积分10
5秒前
孙燕应助猪猪hero采纳,获得10
5秒前
会发光的小灰灰完成签到,获得积分10
5秒前
板凳儿cc发布了新的文献求助10
5秒前
黑色天使发布了新的文献求助10
6秒前
6秒前
激情的代曼完成签到,获得积分10
6秒前
7秒前
10秒前
缓慢手机完成签到,获得积分10
10秒前
丫丫完成签到,获得积分10
10秒前
11秒前
时尚俊驰发布了新的文献求助10
11秒前
耍酷的冷雪完成签到,获得积分10
12秒前
wanci应助baonali采纳,获得10
14秒前
ZONG发布了新的文献求助10
15秒前
wuy发布了新的文献求助10
15秒前
123完成签到,获得积分10
16秒前
17秒前
saisyo发布了新的文献求助10
18秒前
隐形曼青应助炸胡娃娃采纳,获得30
19秒前
坦率白萱应助wwl采纳,获得10
19秒前
NexusExplorer应助小晓采纳,获得10
19秒前
20秒前
20秒前
123发布了新的文献求助10
21秒前
搞怪的紫易完成签到,获得积分10
21秒前
WYQ完成签到,获得积分10
21秒前
幸福大白发布了新的文献求助10
23秒前
玩命的凝天完成签到,获得积分10
23秒前
量子星尘发布了新的文献求助10
23秒前
zxq1996完成签到 ,获得积分10
23秒前
所所应助时尚俊驰采纳,获得10
24秒前
LU41完成签到,获得积分10
25秒前
桑榆完成签到,获得积分10
25秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3989444
求助须知:如何正确求助?哪些是违规求助? 3531531
关于积分的说明 11254250
捐赠科研通 3270191
什么是DOI,文献DOI怎么找? 1804901
邀请新用户注册赠送积分活动 882105
科研通“疑难数据库(出版商)”最低求助积分说明 809174