上皮-间质转换
串扰
癌症研究
炎症
癌变
癌细胞
癌症
生物
肿瘤进展
程序性细胞死亡
重编程
细胞凋亡
细胞
细胞生物学
免疫学
转移
物理
光学
生物化学
遗传学
作者
Nader Ebrahimi,Samaneh Adelian,Siavash Shakerian,Maral Afshinpour,Siavash Rahimian Chaleshtori,Nadi Rostami,Fatemeh Rezaei‐Tazangi,Sheida Beiranvand,Michael R. Hamblin,Amir Reza Aref
标识
DOI:10.1016/j.cytogfr.2022.01.006
摘要
Both genomic instability and the presence of chronic inflammation are involved in carcinogenesis and tumor progression. These alterations predispose the cancer cells to undergo metabolic reprogramming as well as the epithelial-mesenchymal transition (EMT). These pathways allow cancer cells to avoid apoptosis and stimulate tumor progression. EMT is an important early event in tumor cell invasion, which can be regulated through inflammatory signaling pathways. Cancer cells undergoing EMT are vulnerable to cell death by the process of ferroptosis. Ferroptosis is a form of regulated cell death involving iron-dependent lipid peroxidation, designed to maintain cellular homeostasis. Several reports have linked ferroptosis, inflammation, and cancer. Ferroptosis inhibitors and EMT inducers have been used to understand the anti-inflammatory and anticancer effects in experimental models. A better understanding of the crosstalk between ferroptosis and EMT, and the involvment of inflammatory mediators may accelerate the discovery of therapeutic strategies to eradicate cancer cells and overcome drug-resistance.
科研通智能强力驱动
Strongly Powered by AbleSci AI