葛根素
糖尿病性心肌病
炎症
体内
药理学
医学
糖尿病
下调和上调
内科学
心肌病
内分泌学
化学
心力衰竭
生物化学
生物
病理
替代医学
生物技术
基因
作者
Mao-Shan Yin,Yichi Zhang,Shuhong Xu,Jingjing Liu,Xiufa Sun,Chen Liang,Yan Wang,Jie Li,Wang Fu-wen,Qingli Wang,Yuguang Mu
标识
DOI:10.1080/10286020.2017.1405941
摘要
Diabetic cardiomyopathy (DCM) is one of the chief diabetes mellitus complications. Inflammation factors may be one reason for the damage from DM. The purpose of this research is to study the potential protective effects of puerarin on DM and the possible mechanisms of action related to NF-κB signal pathway. Following administration of puerarin to the disease model rat, several changes were observed including the changes of serum biochemical index, improved diastolic dysfunction, and enhanced endogenous antioxidant enzymes activities, further NF-κB signaling activation. Puerarin showed cardio-protective effects on DCM by inhibiting inflammation, and it might be a potential candidate for the treatment of DCM.
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