生物膜
运动性
细胞生物学
信号转导
细胞信号
第二信使系统
小分子
化学
毒力
细菌
生物
微生物学
生物化学
基因
遗传学
作者
Clement Opoku‐Temeng,Herman O. Sintim
出处
期刊:Methods in molecular biology
日期:2017-01-01
卷期号:: 419-430
被引量:26
标识
DOI:10.1007/978-1-4939-7240-1_31
摘要
Bacteria possess several signaling molecules that regulate distinct phenotypes. Cyclic di-GMP (c-di-GMP) has emerged as a ubiquitous second messenger that regulates bacterial virulence, cell cycle, motility, and biofilm formation. The link between c-di-GMP signaling and biofilm formation affords novel strategies for treatment of biofilm-associated infections, which is a major public health problem. The complex c-di-GMP signaling pathway creates a hurdle in the development of small molecule modulators. Nonetheless, some progress has been made in this regard and inhibitors of c-di-GMP metabolizing enzymes that affect biofilm formation and motility have been documented. Herein we discuss the components of c-di-GMP signaling, their correlation with biofilm formation as well as motility and reported small molecule inhibitors of c-di-GMP signaling.
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