对映体
膜
可操作性
手性(物理)
生化工程
工艺工程
比例(比率)
对映体过量
多样性(控制论)
化学
计算机科学
组合化学
有机化学
对映选择合成
工程类
催化作用
物理
人工智能
手征对称破缺
生物化学
量子力学
软件工程
Nambu–Jona Lasinio模型
夸克
作者
Carla Fernandes,Maria Elizabeth Tiritan,Madalena Pinto
出处
期刊:Symmetry
[MDPI AG]
日期:2017-09-30
卷期号:9 (10): 206-206
被引量:58
摘要
Given the importance of chirality in the biological response, regulators, industries and researchers require chiral compounds in their enantiomeric pure form. Therefore, the approach to separate enantiomers in preparative scale needs to be fast, easy to operate, low cost and allow obtaining the enantiomers at high level of optical purity. A variety of methodologies to separate enantiomers in preparative scale is described, but most of them are expensive or with restricted applicability. However, the use of membranes have been pointed out as a promising methodology for scale-up enantiomeric separation due to the low energy consumption, continuous operability, variety of materials and supports, simplicity, eco-friendly and the possibility to be integrated into other separation processes. Different types of membranes (solid and liquid) have been developed and may provide applicability in multi-milligram and industrial scales. In this brief overview, the different types and chemical nature of membranes are described, showing their advantages and drawbacks. Recent applications of enantiomeric separations of pharmaceuticals, amines and amino acids were reported.
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