Metal‐Free Selective C2‐H Amidation of 8‐Amidoquinolines by Using Isocyanide as the Source of Amide

Abstract An unanticipated and highly efficient selective amidation in the C2 position of 8‐amidoquinolines has been developed via C‐H bond elaboration. The method is transition‐metal‐free, operationally simple with broad functional group tolerance. In this work, isocyanide has been successfully utilized as the source of amide. Furthermore, various kinds of 8‐amidoquinolines in combination with different substituted isocyanides under oxidative condition resulted in direct access to N ‐quinoline‐2‐carboxamides in good yields.