Combined Plasma Fibrinogen and Neutrophil Lymphocyte Ratio in Ovarian Cancer Prognosis May Play a Role?

医学 中性粒细胞与淋巴细胞比率 揭穿 内科学 纤维蛋白原 胃肠病学 卵巢癌 中性粒细胞绝对计数 全血细胞计数 淋巴细胞 阶段(地层学) 浆液性液体 人口 癌症 中性粒细胞减少症 化疗 古生物学 生物 环境卫生
作者
Cláudia Marchetti,Alessia Romito,Angela Musella,Giulia Santo,Innocenza Palaia,Giorgia Perniola,Violante Di Donato,Ludovico Muzii,Pierluigi Benedetti Panici
出处
期刊:International Journal of Gynecological Cancer [BMJ]
卷期号:28 (5): 939-944 被引量:26
标识
DOI:10.1097/igc.0000000000001233
摘要

Objectives In ovarian cancer (OC), approximately 70% will relapse within 12 months from diagnosis; inflammation plays an important role in cancer initiating and progression; thus, a combination of neutrophil-to-lymphocyte ratio (NLR) and fibrinogen (F-NLR) has been proposed as prognostic marker in several tumors. The aim of our study was to investigate the correlation between NLR, fibrinogen, and F-NLR and survival in OC population. Methods Patients with diagnosis of OC admitted to our institute between 2011 and 2016 were included. Data about pretreatment complete blood count were collected. Neutrophil-to-lymphocyte ratio was defined as the absolute neutrophil count divided by the absolute lymphocyte count; the F-NLR score was 0 for low NLR and fibrinogen, 1 for low NLR and high fibrinogen, or, conversely, 2 for both high markers. We correlated this index with progression-free survival. Results A total of 94 patients were enrolled. Median age at diagnosis was 55 (34–83) years; more than 80% of patients presented International Federation of Gynecology and Obstetrics stage III–IV at diagnosis, and 72 (77%) presented high-grade serous histology. Primary debulking surgery was performed in 57 women (60%), whereas 37 (40%) underwent interval debulking surgery. Mean serum NLR was 5.25 ± 5.37, and mean serum fibrinogen value was 4.19 ± 0.97 g/L. The median follow-up time was 27 months (range, 8–60 months). All patients with F-NLR value of 2 presented advanced disease compared with 64% of those with F-NLR of 0 ( P < 0.031); these patients more frequently required neoadjuvant chemotherapy ( P < 0.003) and more often had platinum-resistant disease ( P < 0.022). Patients with high F-NLR presented worse progression-free survival than did patients with low F-NLR (12 vs 42 months, respectively, P = 0.023). Conclusions Combining NLR and fibrinogen levels could be used as a factor for prediction of prognosis and response to treatment in patients affected with OC.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
薄雪草完成签到,获得积分10
刚刚
大橙子发布了新的文献求助10
刚刚
快乐学习每一天完成签到 ,获得积分10
刚刚
薄荷味完成签到 ,获得积分0
2秒前
科研通AI2S应助笑林采纳,获得10
2秒前
无心的雅旋完成签到,获得积分10
3秒前
量子星尘发布了新的文献求助10
4秒前
Horizon完成签到 ,获得积分10
8秒前
Oliver完成签到 ,获得积分10
10秒前
Superman完成签到 ,获得积分10
13秒前
Tina酱完成签到 ,获得积分10
13秒前
琪琪完成签到,获得积分10
13秒前
双碳小王子完成签到,获得积分10
15秒前
smottom应助科研通管家采纳,获得10
17秒前
17秒前
明时完成签到,获得积分10
18秒前
杨瑞东完成签到 ,获得积分10
21秒前
yyyy完成签到,获得积分10
29秒前
缥缈的平卉完成签到 ,获得积分10
30秒前
量子星尘发布了新的文献求助10
41秒前
李爱国应助大橙子采纳,获得10
42秒前
magictoo发布了新的文献求助30
48秒前
50秒前
yang完成签到,获得积分10
50秒前
Minicoper发布了新的文献求助10
51秒前
快乐丸子完成签到,获得积分10
52秒前
简单而复杂完成签到,获得积分10
52秒前
大橙子发布了新的文献求助10
56秒前
张牧之完成签到 ,获得积分10
58秒前
冷冷暴力完成签到,获得积分10
1分钟前
YYY完成签到,获得积分10
1分钟前
1分钟前
gujian完成签到 ,获得积分10
1分钟前
帅气的秘密完成签到 ,获得积分10
1分钟前
自然函发布了新的文献求助10
1分钟前
冰冰双双完成签到,获得积分10
1分钟前
开心夏旋完成签到 ,获得积分0
1分钟前
我要读博士完成签到 ,获得积分10
1分钟前
活泼的大船完成签到,获得积分10
1分钟前
AFF完成签到,获得积分10
1分钟前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Handbook of Industrial Diamonds.Vol2 1100
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038128
求助须知:如何正确求助?哪些是违规求助? 3575831
关于积分的说明 11373827
捐赠科研通 3305610
什么是DOI,文献DOI怎么找? 1819255
邀请新用户注册赠送积分活动 892655
科研通“疑难数据库(出版商)”最低求助积分说明 815022