自愈水凝胶
胶粘剂
硼酸
聚合物
自愈
细胞包封
材料科学
化学
纳米技术
高分子化学
化学工程
复合材料
组合化学
病理
替代医学
工程类
医学
图层(电子)
作者
Sang Hyeon Hong,Sun Jin Kim,Joseph P. Park,Mikyung Shin,Keumyeon Kim,Gi-Hyung Ryu,Haeshin Lee
出处
期刊:Biomacromolecules
[American Chemical Society]
日期:2018-03-30
卷期号:19 (6): 2053-2061
被引量:153
标识
DOI:10.1021/acs.biomac.8b00144
摘要
For the increasing demand of soft materials with wide ranges of applications, hydrogels have been developed exhibiting variety of functions (e.g., stretchable, self-healing, stimuli-responsive, and etc.). So far, add-in components such as inorganic nanoparticles, carbon materials, clays, and many others to main polymers have been used to achieve various unique functions of hydrogels. The multicomponent hydrogel systems often exhibit batch-dependent inconsistent results and problems in multicomponent mixings, require labors during preparations, and accompany unpredictable cross-talk between the added components. Here, we developed ‘single polymeric component’, alginate-boronic acid (alginate-BA) hydrogel to overcome the aforementioned problems. It exhibits unprecedented multifunctionalities simultaneously, such as high stretchability, self-healing, shear-thinning, pH- and glucose-sensitivities, adhesive properties, and reshaping properties. Multifunctionalities of alginate-BA hydrogel is resulted from the reversible inter- and intramolecular interactions by dynamic equilibrium of boronic acid–diol complexation and dissociation, which was proved by single molecule level Atomic Force Microscopy (AFM) pulling experiments. We also found that the alginate-BA gel showed enhanced in vivo retentions along gastrointestinal (GI) tract. Our findings suggest that rational polymer designs can result in minimizing the number of a participating component for multifunctional hydrogels, instead of increasing complexity by adding various additional components.
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