Association of insulin-like growth factor-1 and IGF binding protein-3 with 25-hydroxy vitamin D in pre-pubertal and adolescent Indian girls

医学 维生素D与神经学 内科学 内分泌学 体质指数 胰岛素样生长因子 维生素D结合蛋白 胰岛素样生长因子结合蛋白 维生素D缺乏 生长因子 维生素 受体
作者
Raman K. Marwaha,Mahendra Kumar Garg,Sushil K. Gupta,Mohd Ashraf Ganie,Nidhi Gupta,Amit Narang,Manoj Kumar Shukla,Preeti Chawla Arora,Amritpal Singh,Aditi Chadha,Ambrish Mithal
出处
期刊:Journal of Pediatric Endocrinology and Metabolism [De Gruyter]
卷期号:31 (3): 289-295 被引量:7
标识
DOI:10.1515/jpem-2017-0275
摘要

Abstract Background: There is a high prevalence of vitamin D deficiency (VDD) in India. Molecular mechanisms suggest a strong relationship between vitamin D and growth factors. However, there is a paucity of literature with regard to a relationship between insulin-like growth factor-1 (IGF-1), insulin-like growth factor binding protein-3 (IGFBP-3) and vitamin D particularly in subjects with VDD. The objective of the study was to assess the relationship between growth factors and serum vitamin D-parathormone (PTH) status in school girls and study the impact of vitamin D supplementation on growth factors in pre-pubertal girls with VDD. Methods: Our study subjects were apparently healthy school girls aged 6–18 years. The baseline height, weight, body mass index (BMI), pubertal status, serum 25-hydroxy vitamin D (25OHD), PTH, IGF-1 and IGFBP-3 were assessed in 847 girls aged 6–18 years and in 190 pre-pubertal girls with VDD following supplementation. Results: The mean age, BMI and serum 25OHD of girls were 11.5±3.2 years, 18.7±4.8 kg/m 2 and 9.9±5.6 ng/mL, respectively. VDD was observed in 94.6% of girls. Unadjusted serum IGF-1 levels and IGF-1/IGFBP-3 molar ratio were significantly higher in girls with severe VDD as compared to girls with mild-to-moderate VDD. However, these differences disappeared when adjusted for age, height or sexual maturation. The serum IGF-1 and IGFBP-3 levels increased significantly post supplementation with vitamin D. Conclusions: There were no differences in serum IGF-1 levels and the IGF-1/IGFBP-3 molar ratio among VDD categories when adjusted for age, height and sexual maturation in girls. Vitamin D supplementation resulted in a significant increase in serum IGF-1 levels in VDD pre-pubertal girls.
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