Significant volume deflation and redundant inelastic skin is seen after massive weight loss (MWL). These changes parallel those found with natural aging; thus, patients exhibit accelerated facial aging appearance. A facelift procedure may enhance the cervicofacial contour and reduce the apparent age in MWL patients; nonetheless, fully correcting this facial deformity is challenging. Extensive skin undermining is the most critical aspect of the MWL facelift, as it allows the resection of the excess skin and adequate redraping. This article describes the surgical and medical modifications that need to be considered in the MWL facelift to ensure a successful outcome.