立体中心
硅烷
对映选择合成
硅氢加成
硅烷
钪
催化作用
化学
硅
烯烃
有机化学
硅醇
氯硅烷
作者
Gu Zhan,Huai‐Long Teng,Yong Luo,Shao‐Jie Lou,Masayoshi Nishiura,Zhaomin Hou
标识
DOI:10.1002/anie.201807493
摘要
The catalytic asymmetric construction of silicon-stereogenic silanes is of great interest and significance, but has met with only limited success to date. We herein report the enantioselective hydrosilylation of alkenes with dihydrosilanes by a chiral half-sandwich scandium catalyst, which constitutes an efficient and general route for the synthesis of a wide range of enantioenriched silicon-stereogenic silanes from easily accessible starting materials. This reaction features a broad substrate scope, high yields, and high enantioselectivity. Some of the chiral tertiary silane products were also converted into valuable derivatives, such as chiral silanol, quaternary silane, and benzosilole compounds.
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