化学
烷烃
丁烷
脱质子化
溴化物
单晶
质子核磁共振
抗菌活性
碳-13核磁共振
分子
丙烷
药物化学
晶体结构
结晶学
立体化学
有机化学
细菌
碳氢化合物
催化作用
离子
生物
遗传学
作者
Yen Lee Loh,Umie F.M. Haziz,Rosenani A. Haque,Amirul Al‐Ashraf Abdullah,O.Noor Aidda,Mohd. R. Razali
标识
DOI:10.1080/00958972.2019.1599109
摘要
Three bisbenzimidazolium salts, 3,3-(alkane-1,n-diyl)bisbenzylbenzimidazolium dibromide/dihexafluorophosphate (1a/b–3a/b) (where alkane = ethane, propane or butane and n = 2, 3, or 4), were synthesized. The bromide salts were subsequently used as precursors to prepare their respective Ag(I)-NHC complexes via in situ deprotonation method. The successful formation of all bisbenzimidazolium salts and complexes were proved by elemental analysis, 1H-NMR, 13C-NMR and FT-IR analyses. From single-crystal X-ray diffraction analyses, 4 has been established as a binuclear complex with the molecule arranged as in trans-conformation. Salts 1b–3b and Ag(I)-NHC complexes 4–6 were then screened for their antibacterial potential against E. coli (ATCC 25922) and S. aureus (ATCC 12600). All the bisbenzimidazolium salts do not show any activity against both bacteria while 4 exhibits the highest activity against both bacteria in all methods followed by 5 and 6.
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