阿比坦
大戟科
细胞毒性
立体化学
化学
绝对构型
萜类
大戟
电喷雾质谱
质谱法
乙酸乙酯
二维核磁共振波谱
细胞培养
生物
电喷雾
植物
体外
生物化学
色谱法
遗传学
作者
Minghui Li,Fang He,Yuan Zhou,Meigui Wang,Pingde Tao,Qingmei Tu,Guanghui Lv,Xintao Chen
标识
DOI:10.1007/s12272-019-01151-y
摘要
Three new ent-abietane diterpenoids, termed fischerianoids A–C (1–3), were isolated and identified from the ethyl acetate extracts of roots of the medicinally valuable plant Euphorbia fischeriana. The planar and relative structures of 1–3 were established via high-resolution electrospray ionisation mass spectrometry and one- and two-dimensional nuclear magnetic resonance spectroscopic analyses, and the absolute configuration of 1 was further established via X-ray crystallography experiment. Compounds 1–3 showed selective inhibitory potency against certain human tumor cell lines with IC50 values ranging from 8.50 ± 0.13 to 35.52 ± 0.08 μM.
科研通智能强力驱动
Strongly Powered by AbleSci AI