神经科学
疾病
病态的
Tau病理学
阿尔茨海默病
τ蛋白
淀粉样蛋白(真菌学)
医学
心理学
病理
作者
Nima Naseri,Hong Wang,Jennifer D. Guo,Manu Sharma,Wenjie Luo
标识
DOI:10.1016/j.neulet.2019.04.022
摘要
Alzheimer's disease (AD) is characterized by two major pathological lesions in the brain, amyloid plaques and neurofibrillary tangles (NFTs) composed mainly of amyloid-β (Aβ) peptides and hyperphosphorylated tau, respectively. Although accumulation of toxic Aβ species in the brain has been proposed as one of the important early events in AD, continued lack of success of clinical trials based on Aβ-targeting drugs has triggered the field to seek out alternative disease mechanisms and related therapeutic strategies. One of the new approaches is to uncover novel roles of pathological tau during disease progression. This review will primarily focus on recent advances in understanding the contributions of tau to AD.
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