医学
糖尿病肾病
糖尿病
肾病
梅德林
重症监护医学
内分泌学
生物化学
化学
作者
Vasilios Papademetriou,Sofia Alataki,Konstantinos Stavropoulos,Christodoulos Papadopoulos,Kostas Bakogiannis,Konstantinos Tsioufis
出处
期刊:Current Vascular Pharmacology
[Bentham Science]
日期:2020-01-27
卷期号:18 (2): 139-147
被引量:9
标识
DOI:10.2174/1570161117666190405164749
摘要
Diabetes mellitus (DM) is one of the most common diseases worldwide. Its adverse effects on several body organs, have made treatment of DM a priority. One of the most serious complications of DM is diabetic nephropathy (DN).The aim of this review is to critically discuss available data on the pharmacological management of DN.A comprehensive review of the literature was performed to identify studies assessing the impact of several drug classes on DN.Several studies have been conducted in order to find a novel and effective treatment of DN. So far, the cornerstone therapy of DN consists of renin-angiotensin system (RAS) inhibitors, agents that decrease the synthesis of intrarenal angiotensin II or block its receptors. Their antiproteinuric and antihypertensive effects can not only decelerate the progress of DN but prevent its onset as well. Novel antidiabetic drugs, such as sodium-glucose cotransporter 2 inhibitors (SGLT-2i) and glucagon-like peptide- 1 receptor agonists (GLP-1 RA), are promising agents in the therapy of DN, due to their positive effect on renal and cardiovascular adverse events. From lipid-lowering agents, atorvastatin improves DN up to stage 3 and substantially reduces CVD.RAS inhibitors, SGLT-2i and GLP-1 agonists were found to be beneficial for the treatment of DN. Larger renal trials are needed in order to incorporate these drugs into the first line treatment of DN.
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