硼酸
胶束
化学
二醇
胰岛素释放
胰岛素
苯硼酸
有机化学
组合化学
催化作用
糖尿病
水溶液
医学
内分泌学
1型糖尿病
作者
Heba Gaballa,Patrick Théato
出处
期刊:Biomacromolecules
[American Chemical Society]
日期:2019-01-04
卷期号:20 (2): 871-881
被引量:62
标识
DOI:10.1021/acs.biomac.8b01508
摘要
In the present study, glucose-responsive polymeric complex micelles based on the complexation of phenylboronic-acid-based (PBA-based) block copolymer and diol-functionalized polymers are reported. The phenylboronic-acid- and diol-based block copolymers were successfully synthesized in only two reaction steps using reversible addition–fragmentation chain-transfer (RAFT) polymerization and postpolymerization modification of the obtained poly[(N-acryloylmorpholine-block-(N-acryloylmorpholine-co-pentafluorophenyl acrylate)], poly[(AMP-b-(AMP-co-PFPA)], reactive block copolymer. The self-assembly of the complex micelles was investigated under neutral conditions using dynamic light scattering (DLS) and transmission electron microscopy (TEM). The interaction of the PBA block copolymer and diol-containing polymer via boronate ester bond was investigated by 1H NMR and UV–vis spectroscopy. The complex micelles enhanced the glucose responsiveness under physiological conditions compared to simple PBA micelles. Furthermore, the successful glucose-triggered release of FITC–insulin from the polymeric micelles was investigated.
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