Callicarpa nudiflora loaded on chitosan-collagen/organomontmorillonite composite membrane for antibacterial activity of wound dressing

Abstract A biopolymer membrane chitosan-collagen/organomontmorillonite loaded with Callicarpa nudiflora (CS-COL/CN-OMMT) was prepared as a wound dressing. Three composite membranes including chitosan-collagen (CS-COL), chitosan-collagen/montmorillonite (CS-COL/MMT) and chitosan-collagen/organomontmorillonite (CS-COL/OMMT) were studied from physicochemical, swelling ratio, degradation ratio in vitro and moisture permeability properties. The CS-COL/OMMT composite membrane with porous layered structure exhibited a significantly higher swelling ratio, lower degradation ratio and rather excellent moisture permeability properties than other membranes. Callicarpa nudiflora were loaded on CS-COL/OMMT composite membrane to improve antibacterial activity from 20.20 ± 0.50% to 68.60 ± 0.10%.