化学
烷基
催化作用
β-氢化物消除
催化循环
药物化学
赫克反应
有机化学
芳基
作者
Haigen Xiong,Yajun Li,Bo Qian,Rongbiao Wei,Erik V. Van der Eycken,Hongli Bao
出处
期刊:Organic Letters
[American Chemical Society]
日期:2019-01-22
卷期号:21 (3): 776-779
被引量:33
标识
DOI:10.1021/acs.orglett.8b04024
摘要
An iron(II)-catalyzed radical alkyl Heck-type reaction of alkyl iodides with vinylarenes under mild conditions has been reported. t-Butyl peroxybenzoate (TBPB) behaves simultaneously as a radical relay initiator, a precursor for the generation of alkyl radical from alkyl iodides, and an oxidant to recycle iron(II)/iron(III). Unactivated primary, secondary, and tertiary alkyl iodides are compatible with the reaction conditions. The mechanistic studies suggest that a radical-polar-crossover pathway might be involved in the catalytic cycle.
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