Significant Associations Between the A163G and G1181C Polymorphisms of the Osteoprotegerin Gene and Risk of Osteoporosis, Especially in Postmenopausal Women: A Meta-Analysis

骨保护素 骨质疏松症 荟萃分析 医学 优势比 等位基因 内科学 科克伦图书馆 置信区间 病例对照研究 多态性(计算机科学) 肿瘤科 生物信息学 遗传学 基因 生物 受体 激活剂(遗传学)
作者
Yi Luo,Zhenming Hu,Jie Hao,Wei Jiang,Jieliang Shen,Jun Zhao
出处
期刊:Genetic Testing and Molecular Biomarkers [Mary Ann Liebert, Inc.]
卷期号:18 (3): 211-219 被引量:16
标识
DOI:10.1089/gtmb.2013.0420
摘要

Whereas some studies have reported that the osteoprotegerin (OPG) gene is associated with osteoporosis risk in some studies, their results have proved inconclusive. We performed a meta-analysis of studies on the associations between OPG A163G and G1181C polymorphisms and the risk of osteoporosis.A literature search in PubMed, Embase, Web of Science, Cochrane Library, and China Biological Medicine (CBM) databases was conducted to identify all eligible case-control studies published before August 15th, 2013. Pooled odds ratios with their corresponding 95% confidence intervals were used to evaluate the strength of the association under either a fixed- or random-effect model according to the heterogeneity test.Ten case-control studies were included with a total of 1673 osteoporosis cases and 1554 healthy controls in this meta-analysis. For the OPG A163G polymorphism, the combined results showed that the G allele of the A163G polymorphism may be associated with an increased risk of osteoporosis. Stratified analyses showed that the magnitude of the effect was similar among the Caucasian and postmenopausal women subgroups. Unlike the A163G polymorphism, the meta-analysis results revealed that the C allele of the G1181C polymorphism may be associated with a decreased risk of osteoporosis, especially in the Asian and postmenopausal women subgroups. No publication bias was detected for either polymorphism.Our findings showed that the G allele of the OPG A163G polymorphism may increase osteoporosis risk, whereas the C allele of the G1181C polymorphism may protect individuals from osteoporosis. Both of these effects were observed in postmenopausal women.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
张小斌完成签到,获得积分10
1秒前
奋斗水香完成签到,获得积分10
1秒前
沈文远发布了新的文献求助10
2秒前
orixero应助qq采纳,获得10
3秒前
Inoron完成签到 ,获得积分10
4秒前
4秒前
morris发布了新的文献求助10
4秒前
5秒前
机智的乌完成签到,获得积分10
5秒前
量子星尘发布了新的文献求助10
6秒前
清爽的机器猫完成签到 ,获得积分10
6秒前
竹子完成签到,获得积分10
7秒前
7秒前
8秒前
8秒前
gsonix发布了新的文献求助10
9秒前
morris完成签到,获得积分10
10秒前
热心的十二完成签到 ,获得积分10
10秒前
11秒前
Selenaxue发布了新的文献求助10
11秒前
12秒前
魔飞发布了新的文献求助10
13秒前
ClaudiaCY发布了新的文献求助10
14秒前
msy完成签到,获得积分10
14秒前
qqxx应助沈文远采纳,获得10
14秒前
qq发布了新的文献求助10
14秒前
炙热柚子完成签到,获得积分10
15秒前
CyrusSo524应助此间少年郎采纳,获得50
16秒前
17秒前
大王可爱完成签到,获得积分10
18秒前
纯情的严青完成签到,获得积分10
18秒前
风息发布了新的文献求助10
18秒前
JamesPei应助小崔采纳,获得10
19秒前
19秒前
阿明完成签到,获得积分10
19秒前
fmy完成签到,获得积分10
20秒前
21秒前
21秒前
22秒前
儒雅寒天发布了新的文献求助10
23秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Cognitive Neuroscience: The Biology of the Mind 1000
Technical Brochure TB 814: LPIT applications in HV gas insulated switchgear 1000
Toward a Combinatorial Approach for the Prediction of IgG Half-Life and Clearance 500
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Picture Books with Same-sex Parented Families: Unintentional Censorship 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3969917
求助须知:如何正确求助?哪些是违规求助? 3514626
关于积分的说明 11175060
捐赠科研通 3249928
什么是DOI,文献DOI怎么找? 1795165
邀请新用户注册赠送积分活动 875617
科研通“疑难数据库(出版商)”最低求助积分说明 804891