Significant Associations Between the A163G and G1181C Polymorphisms of the Osteoprotegerin Gene and Risk of Osteoporosis, Especially in Postmenopausal Women: A Meta-Analysis

骨保护素 骨质疏松症 荟萃分析 医学 优势比 等位基因 内科学 科克伦图书馆 置信区间 病例对照研究 多态性(计算机科学) 肿瘤科 生物信息学 遗传学 基因 生物 受体 激活剂(遗传学)
作者
Yi Luo,Zhenming Hu,Jie Hao,Wei Jiang,Jieliang Shen,Jun Zhao
出处
期刊:Genetic Testing and Molecular Biomarkers [Mary Ann Liebert, Inc.]
卷期号:18 (3): 211-219 被引量:16
标识
DOI:10.1089/gtmb.2013.0420
摘要

Whereas some studies have reported that the osteoprotegerin (OPG) gene is associated with osteoporosis risk in some studies, their results have proved inconclusive. We performed a meta-analysis of studies on the associations between OPG A163G and G1181C polymorphisms and the risk of osteoporosis.A literature search in PubMed, Embase, Web of Science, Cochrane Library, and China Biological Medicine (CBM) databases was conducted to identify all eligible case-control studies published before August 15th, 2013. Pooled odds ratios with their corresponding 95% confidence intervals were used to evaluate the strength of the association under either a fixed- or random-effect model according to the heterogeneity test.Ten case-control studies were included with a total of 1673 osteoporosis cases and 1554 healthy controls in this meta-analysis. For the OPG A163G polymorphism, the combined results showed that the G allele of the A163G polymorphism may be associated with an increased risk of osteoporosis. Stratified analyses showed that the magnitude of the effect was similar among the Caucasian and postmenopausal women subgroups. Unlike the A163G polymorphism, the meta-analysis results revealed that the C allele of the G1181C polymorphism may be associated with a decreased risk of osteoporosis, especially in the Asian and postmenopausal women subgroups. No publication bias was detected for either polymorphism.Our findings showed that the G allele of the OPG A163G polymorphism may increase osteoporosis risk, whereas the C allele of the G1181C polymorphism may protect individuals from osteoporosis. Both of these effects were observed in postmenopausal women.
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