医学
骨质疏松症
维生素D与神经学
生物标志物
前瞻性队列研究
内科学
骨重建
物理疗法
生物化学
化学
作者
Daniel Sacks,Kourosh Parham
出处
期刊:Otology & Neurotology
[Ovid Technologies (Wolters Kluwer)]
日期:2015-09-01
卷期号:36 (9): 1532-1536
被引量:28
标识
DOI:10.1097/mao.0000000000000853
摘要
To test the hypothesis that levels of a BPPV biomarker, otolin-1, correlate with those of osteoporosis markers, aminoterminal propeptide of protocollagen type I (P1NP), and aminoterminal telopeptides of collagen (NTX), thus further supporting a link between the two diseases.Prospective pilot clinical trial (Level of Evidence: 2b).Postmenopausal women with BPPV.Diagnostic.Serum levels of otolin-1, P1NP, NTX, vitamin D, and calcium were examined in relation to each other, age, and DEXA scan T-scores.There was a strong, negative correlation between T-scores and otolin-1 levels. Although P1NP and NTX levels were strongly correlated, neither had statistical correlations with otolin-1.Despite a strong correlation between DEXA scan results and otolin-1 levels, there were no significant correlations between otolin-1 and P1NP or NTX. This suggests that the association between osteoporosis and BPPV is complex, but not likely to be causal. Although more work is needed to elucidate these relationships, this preliminary finding has important practical implications for BPPV in that proactive management of osteoporosis, per se, would not be expected to have benefits in management of BPPV.
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