炎症体
NLRC4型
生物
目标2
分泌物
先天免疫系统
MUC1号
粘蛋白
微生物学
免疫系统
炎症
细菌
细胞生物学
半胱氨酸蛋白酶1
免疫学
生物化学
遗传学
作者
Garrett Z. Ng,Philip Sutton
摘要
MUC1 is a cell membrane-associated mucin, expressed ubiquitously on the mucosal epithelia as well as by immune cells, that limits the inflammatory response to multiple pathogens. We have recently shown that MUC1 controls inflammation resulting from Helicobacter pylori infection by suppressing interleukin-1β (IL-1β) produced via the NLRP3 inflammasome. Here, we demonstrate that MUC1 also regulates IL-1β secretion induced by the NLRP3-activating bacteria Haemophilus influenzae but not bacteria that activate other inflammasomes. Using purified ligands, we further demonstrate that MUC1 regulation of NLRP3 is specific, as it has no effect on the NLRP1b, NLRC4 and AIM2 inflammasomes. This indicates a unique role for MUC1 in the regulation of NLRP3-activating bacterial infections.
科研通智能强力驱动
Strongly Powered by AbleSci AI