IMRT vs. 2D-radiotherapy or 3D-conformal radiotherapy of nasopharyngeal carcinoma

医学 鼻咽癌 放射治疗 多元分析 肿瘤科 内科学 核医学 泌尿科 放射科
作者
Sung Ho Moon,Kwan Ho Cho,Chang Geol Lee,Ki Chang Keum,Yeon‐Sil Kim,Hong-Gyun Wu,Jin Ho Kim,Yong Chan Ahn,Dongryul Oh,Jong Hoon Lee
出处
期刊:Strahlentherapie Und Onkologie [Springer Science+Business Media]
卷期号:192 (6): 377-385 被引量:47
标识
DOI:10.1007/s00066-016-0959-y
摘要

We compared treatment outcomes of two-dimensional radiotherapy (2D-RT), three-dimensional conformal radiotherapy (3D-CRT), and intensity-modulated radiotherapy (IMRT) in patients with nasopharyngeal carcinoma (NPC). In total, 1237 patients with cT1-4N0-3M0 NPC were retrospectively analyzed. Of these, 350, 390, and 497 were treated with 2D-RT, 3D-CRT, and IMRT, respectively. 3D-CRT and IMRT showed better 5-year overall survival (OS) rates (73.6 and 76.7 %, respectively) than did 2D-RT (5-year OS of 59.7 %, all p < 0.001). In T3–4 subgroup, IMRT was associated with a significantly better 5-year OS than was 2D-RT (70.7 vs. 50.4 %, respectively; p ≤ 0.001) and 3D-CRT (70.7 vs. 57.8 %, respectively; p = 0.011); however, the difference between the 2D-RT and 3D-CRT groups did not reach statistical significance (p = 0.063). In multivariate analyses of all patients, IMRT was a predictive factor for OS when compared with 2D-RT or 3D-CRT, as was 3D-CRT when compared with 2D-RT. Our study showed that 3D-CRT and IMRT were associated with a better local progression-free survival and OS than was 2D-RT in NPC. IMRT was significantly superior in terms of OS for advanced primary tumors (T3–4).
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