乙酰胆碱酯酶
阿切
敌敌畏
效力
胆碱酯酶
内分泌学
化学
内科学
乙酰胆碱酯酶抑制剂
酶
酶分析
药理学
生物
杀虫剂
生物化学
体外
医学
农学
作者
Karen Larsen,Adrián Luis Lifschitz,Carlos Lanusse,G. Virkel
标识
DOI:10.1016/j.etap.2016.05.012
摘要
The current work evaluated the inhibitory potency of the herbicide glyphosate (GLP) on acetylcholinesterase (AChE) activity in male and female rat tissues. The AChE activity in brain was higher (p < 0.05) than those observed in kidney (females: 2.2-fold; males: 1.9-fold), liver (females: 6-fold; males: 6.9-fold) and plasma (females: 14.7-fold; males: 25.3-fold). Enzyme activities were higher in presence of 10 mM GLP compared to those measured at an equimolar concentration of the potent AChE inhibitor dichlorvos (DDVP). Moreover, IC50s for GLP resulted between 6 × 104- and 6.8 × 105-fold higher than those observed for DDVP. In conclusion, GLP is a weak inhibitor of AChE in rats.
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