医学
哮喘
舌下免疫疗法
狭缝
不利影响
入射(几何)
舌下给药
随机对照试验
免疫疗法
内科学
遗传学
生物
光学
物理
癌症
出处
期刊:Journal of Jilin University
日期:2013-01-01
被引量:1
摘要
Objective To observe the clinical efficacy and safety of long-term sublingual immunotherapy with dermatophagoides farinae drops in children with bronchial asthma and to provide a safe and effective method to treat bronchial asthma in children.Methods A two-year randomized and parallel-controlled study was conducted in 128 children(aged 4-14 years) with mild to moderate asthma symptoms.The patients were randomly assigned to treatment group and control group(n=64).The patients in treatment group were treated with sublingual immunotherapy(SLIT) with dermatophagoides farinae drops.The patients in control group were treated according the manufacturer' s instructions.The clinical efficacy was evaluated by monthly follow-up visits.After treatment for 6 months,1 year and 2 years using dermatophagoides farinae drops,the asthma symptom scores and PEF% were evaluated.Results Of the 128 children,5 cases dropped out before the study completion.After 6 months,1 year and 2 years of treatment,the allergic asthma symptom scores of the patients in treatment group were significantly decreased compared with control group(P0.05).After 6 months,1 year and 2 years of treatment,the PEF% of the patients in treatment group were singnificantly increased compared with control group(P0.05).There were no severe adverse events during the course of immunotherapy,except for mild reactions.Conclusion Long-term sublingual immunotherapy with dermatophagoides farinae drops can significantly improve symptoms and lung function in children with asthma,and lower the incidence of adverse reactions,so it is effective and safe in the treatment of children with bronchial asthma.
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