基质
血管生成
血管
血管内皮生长因子
血管通透性
病理
结缔组织
间质细胞
新生血管
生物
医学
癌症研究
血管内皮生长因子受体
内分泌学
免疫组织化学
出处
期刊:The cancer journal
[Ovid Technologies (Wolters Kluwer)]
日期:2015-07-01
卷期号:21 (4): 237-243
被引量:89
标识
DOI:10.1097/ppo.0000000000000124
摘要
Solid tumors generally require a vascularized connective tissue stroma if they are to grow beyond minimal size. They generate that stroma in part by secreting vascular endothelial growth factor (VEGF), a potent vascular permeability and angiogenic factor. Increased vascular permeability leads to deposition of a provisional fibrin stroma, which supports tumor, connective tissue, and inflammatory cell migration and plays an active role in the formation of mature vascularized stroma. Vascular endothelial growth factor–induced tumor blood vessels are heterogeneous, of at least 6 distinct types, and develop linearly over time. They include both angiogenic (mother vessels, glomeruloid microvascular proliferations, vascular malformations, capillaries) and arteriovenogenic (feeding arteries, draining veins) blood vessels. Attacking the tumor vasculature with drugs that target VEGF or its receptors (VEGFR) has come into vogue but has been less effective than had been hope for. One reason for this is that anti-VEGF/VEGFR therapy attacks only a subset of tumor blood vessels, the earliest to form. New targets on late-forming blood vessels such as feeding arteries would be useful in helping antivascular cancer therapy fulfill its promise.
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